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KMID : 0545120120220111482
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Journal of Microbiology and Biotechnology
2012 Volume.22 No. 11 p.1482 ~ p.1485
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An Antitumor Component from Fomitiporia ellipsoidea
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Lifeng Zan
Haiying Bao
Tolgor Bau
Hanbin Liu
Baokai Cui
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Abstract
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A natural furan derivative was isolated from the methanolic extract of the fruit bodies of Fomitiporia ellipsoidea. Its chemical structure was elucidated as methyl 3,5-dioxo- 1,3,5,7-tetrahydrobenzo[1,2-c:4,5-c']difuran-4-carboxylate by means of extensive NMR and MS data analysis, and named as fomitiporiaester A (1). Compound 1 showed significant antitumor activity to hepatoma H22 in vivo, and the inhibition rates were 42.94%, 49.17%, and 58.15% at concentrations of 5, 10, and 20 mg/kg, respectively. Compound 1 showed weak cytotoxic activities against the human hepatoblastoma (HepG-2) and human oophoroma (Skov 3) cell lines with IC50 values of more than 100 μM.
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KEYWORD
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Fomitiporia ellipsoidea, furan ester, antitumor
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